fmlp receptor การใช้

• FPR2, which is now termed the ALX, ALX / FPR, or ALX / FPR2 receptor, is a G protein coupled receptor initially identified as a receptor for the leukocyte chemotactic factor, N-Formylmethionine-leucyl-phenylalanine ( FMLP ), based on its amino acid sequence similarity to the known FMLP receptor, FPR1.
• FMLP led to the first discovery of a leukocyte receptor for a chemotactic factor, defined three different types of FMLP receptors that have complimentary and / or opposing effects on inflammatory responses as well as many other activities, and helped define the stimulus-response coupling mechanisms by which diverse chemotactic factors and their G protein coupled receptors induce cellular function.
• Follow-up studies found that the genes of mitochondria and chloroplasts organelles of Eukaryote cells, including those of humans, which, unlike nuclear genes, code for N-formyl-methionine proteins, release N-formyl-methionyl containing peptides with chemotactic activities that exactly mimic those of FMLP chemotaxis These organelle-derived formylated peptides are true analogs of FMLP that operate through FMLP receptors to recruit circulating blood leukocytes to and thereby initiate inflammation responses at sites of cell damage and tissue destruction not caused by bacteria.